STUDIES ON ANTIALLERGIC COMPONENTS IN THE ROOTS OF ASIASARUM-SIEBOLDI

被引：84

作者：

HASHIMOTO, K ^{[1
]}

YANAGISAWA, T ^{[1
]}

OKUI, Y ^{[1
]}

IKEYA, Y ^{[1
]}

MARUNO, M ^{[1
]}

FUJITA, T ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 60601,JAPAN

来源：

PLANTA MEDICA | 1994年 / 60卷 / 02期

关键词：

ASIASARI RADIX; ASIASARUM SIEBOLDI; ARISTOLOCHIACEAE; ANTIALLERGIC ACTIVITY; PCA; 5-LOX; LTD(4);

D O I：

10.1055/s-2006-959432

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD(4).

引用

页码：124 / 127

页数：4

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