STUDIES ON ANTIALLERGIC COMPONENTS IN THE ROOTS OF ASIASARUM-SIEBOLDI

被引:83
作者
HASHIMOTO, K [1 ]
YANAGISAWA, T [1 ]
OKUI, Y [1 ]
IKEYA, Y [1 ]
MARUNO, M [1 ]
FUJITA, T [1 ]
机构
[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 60601,JAPAN
关键词
ASIASARI RADIX; ASIASARUM SIEBOLDI; ARISTOLOCHIACEAE; ANTIALLERGIC ACTIVITY; PCA; 5-LOX; LTD(4);
D O I
10.1055/s-2006-959432
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD(4).
引用
收藏
页码:124 / 127
页数:4
相关论文
共 20 条
[1]   SYNTHESIS OF 17ALPHA-ACETOXY-6-CHLORO-2ALPHA,3BETA-DIHYDROXY-4,6-PREGNADIEN-20-ONE,A METABOLITE OF CHLORMADINONE ACETATE [J].
ABE, T ;
KAMBEGAW.A .
CHEMICAL & PHARMACEUTICAL BULLETIN, 1973, 21 (06) :1295-1299
[2]   STUDIES IN ASIASARUM (ARISTOLOCHIACEAE) .1. 3 NEW COMPOUNDS IN ASIASARUM-HETEROPOIDES [J].
ENDO, J ;
NAKAMURA, T .
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1978, 98 (06) :789-793
[3]   UBER DIE DARSTELLUNG AROMATISCHER POLYHYDROXYVERBINDUNGEN UND POLYHYDROXYCARBONSAUREN .8. UBER DIE DARSTELLUNG KERNSUBSTITUIERTER ZIMTALDHYDE [J].
FRIEDRICH, K ;
HARTMANN, W .
CHEMISCHE BERICHTE-RECUEIL, 1961, 94 (03) :838-839
[4]  
FURUKAWA M, 1984, BIOCHIM BIOPHYS ACTA, V795, P458
[5]   LAURACEAE - CHEMISTRY OF BRAZILIAN LAURACEAE .19. CONSTITUENTS OF ANIBA-HOSTMANNIANA [J].
GOTTLIEB, OR ;
DAROCHA, AI .
PHYTOCHEMISTRY, 1972, 11 (05) :1861-&
[6]  
HARBONE JB, 1960, BIOCHEM J, V76, P53
[7]  
HASEGAWA Y, 1991, CHEM PHARM BULL, V39, P3180
[8]   MONOTERPENES FROM ASIASARI RADIX FROM ASIASARUM SP [J].
HASHIMOTO, K ;
KATSUHARA, T ;
ITOH, H ;
IKEYA, Y ;
OKADA, M ;
MITSUHASHI, H .
PHYTOCHEMISTRY, 1990, 29 (11) :3571-3574
[9]   THE CONSTITUENTS OF ASIASARUM-SIEBOLDI .2. GLYCOSIDES FROM ROOTS OF ASIASARUM-SIEBOLDI [J].
HASHIMOTO, K ;
KATSUHARA, T ;
NIITSU, K ;
IKEYA, Y ;
OKADA, M ;
MITSUHASHI, H .
PHYTOCHEMISTRY, 1992, 31 (07) :2477-2480
[10]  
HASHIMOTO K, UNPUB PHYTOCHEMISTRY