ENTIRE NUCLEOTIDE-SEQUENCE AND CHARACTERIZATION OF A HEPATITIS-C VIRUS OF GENOTYPE V/3A

被引：97

作者：

SAKAMOTO, M

AKAHANE, Y

TSUDA, F

TANAKA, T

WOODFIELD, DG

OKAMOTO, H

机构：

[1] JICHI MED SCH,DIV IMMUNOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[2] YAMANASHI MED COLL,DEPT INTERNAL MED 1,YAMANASHI 40938,JAPAN

[3] VIRAL HEPATITIS RES FDN JAPAN,TOKYO 113,JAPAN

[4] JAPANESE RED CROSS SAITAMA BLOOD CTR,URAWA,SAITAMA 338,JAPAN

[5] REG BLOOD CTR,DEPT TRANSFUS MED,AUCKLAND,NEW ZEALAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1994年 / 75卷

关键词：

D O I：

10.1099/0022-1317-75-7-1761

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The entire nucleotide sequence of a hepatitis C virus (HCV) genome (NZL1) of genotype V/3a was determined from overlapping cDNA clones obtained from a human carrier in New Zealand. It comprised 9425 nucleotides (nt) including a 5'-untranslated region of 339 nt, a single large open reading frame encoding a polyprotein of 3021 amino acids, a 3'-untranslated region of 23 nt, and 3'-terminal poly(U) stretches of variable lengths. The NZL1 genome was compared with 15 HCV isolates of other genotypes for which the full-length sequence has been determined. It differed from them by 31.1 to 34.3% in nucleotide sequence identity and by 24.5 to 29.1% in amino acid sequence identity, confirming the distinction of genotype V/3a from the other isolates.

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页码：1761 / 1768

页数：8

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