THE ORPHAN NUCLEAR RECEPTOR ROR-ALPHA (RORA) MAPS TO A CONSERVED REGION OF HOMOLOGY ON HUMAN-CHROMOSOME 15Q21-Q22 AND MOUSE CHROMOSOME-9

被引：33

作者：

GIGUERE, V

BEATTY, B

SQUIRE, J

COPELAND, NG

JENKINS, NA

机构：

[1] MCGILL UNIV,DEPT BIOCHEM,MONTREAL,PQ H3A 1A1,CANADA

[2] MCGILL UNIV,DEPT MED,MONTREAL,PQ H3A 1A1,CANADA

[3] MCGILL UNIV,DEPT ONCOL,MONTREAL,PQ H3A 1A1,CANADA

[4] HOSP SICK CHILDREN,CGAT FISH MAPPING RESOURCE CTR,TORONTO,ON M5G 1X8,CANADA

[5] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702

来源：

GENOMICS | 1995年 / 28卷 / 03期

关键词：

D O I：

10.1006/geno.1995.1197

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

ROR alpha is a novel member of the steroid/thyroid/retinoid receptor superfamily with unique DNA-binding properties. We have mapped the RORA gene by fluorescence in situ hybridization to human chromosome 15q21-q22. To map the mouse Rora gene, a partial mouse cDNA clone was isolated from brain. Using interspecific backcross analysis, we have mapped the Rora gene 60 mouse chromosome 9. This places the human RORA gene in the proximity of the PML gene, which is involved in a reciprocal chromosomal translocation t(15:17) with the RARA gene in patients with acute promyelocytic leukemia. (C) 1995 Academic Press, Inc.

引用

页码：596 / 598

页数：3

共 13 条

[1] RAPID PHYSICAL MAPPING OF CLONED DNA ON BANDED MOUSE CHROMOSOMES BY FLUORESCENCE INSITU HYBRIDIZATION [J].