CHRONIC TREATMENT WITH THIOCTIC ACID DOES NOT PROTECT AGAINST MALONATE TOXICITY IN-VIVO

被引：1

作者：

ANGEL, R

GREENAMYRE, JT

机构：

[1] UNIV ROCHESTER,MED CTR,PROGRAM NEUROSCI,ROCHESTER,NY 14642

[2] UNIV ROCHESTER,MED CTR,DEPT NEUROL,ROCHESTER,NY 14642

[3] UNIV ROCHESTER,MED CTR,DEPT PHARMACOL,ROCHESTER,NY 14642

[4] UNIV ROCHESTER,MED CTR,DEPT NEUROBIOL & ANAT,ROCHESTER,NY 14642

来源：

NEUROSCIENCE LETTERS | 1995年 / 196卷 / 1-2期

关键词：

THIOCTIC ACID; DIHYDROLIPOIC ACID; NMDA; MALONIC ACID; EXCITOTOXICITY; MITOCHONDRIA; FREE RADICALS;

D O I：

10.1016/0304-3940(95)11863-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We reported previously that short-term systemic pretreatment with thioctic acid is protective against NMDA and malonate lesions of the striatum. In the current study, we examined the effects of 3 weeks of pretreatment with various doses of thioctic acid (5-60 mg/kg per day) on malonate-induced striatal degeneration in adult rats. Tn this paradigm, we were unable to demonstrate protection against malonate toxicity. The reasons for the difference in efficacy between subacute and chronic treatment remain to be defined.

引用

页码：125 / 127

页数：3

共 13 条

[1] INTERPLAY BETWEEN LIPOIC ACID AND GLUTATHIONE IN THE PROTECTION AGAINST MICROSOMAL LIPID-PEROXIDATION
BAST, A
HAENEN, GRMM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 963 (03) : 558 - 561
[2] BORBE HO, 1995, IN PRESS ARZNEIM FOR
[3] BUSSE E, 1992, ARZNEIMITTELFORSCH, V42-1, P829
[4] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM
CHOI, DW
[J]. NEURON, 1988, 1 (08) : 623 - 634
[5] THE ENDOGENOUS COFACTORS, THIOCTIC ACID AND DIHYDROLIPOIC ACID, ARE NEUROPROTECTIVE AGAINST NMDA AND MALONIC-ACID LESIONS OF STRIATUM
GREENAMYRE, JT
GARCIAOSUNA, M
GREENE, JG
[J]. NEUROSCIENCE LETTERS, 1994, 171 (1-2) : 17 - 20
[6] ALPHA-LIPOIC ACID REDUCTION BY MAMMALIAN-CELLS TO THE DITHIOL FORM, AND RELEASE INTO THE CULTURE-MEDIUM
HANDELMAN, GJ
HAN, D
TRITSCHLER, H
PACKER, L
[J]. BIOCHEMICAL PHARMACOLOGY, 1994, 47 (10) : 1725 - 1730
[7] STANDARD REDOX POTENTIAL OF CYSTEINE-CYSTINE FROM THIOL-DISULPHIDE EXCHANGE REACTION WITH GLUTATHIONE AND LIPOIC ACID
JOCELYN, PC
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1967, 2 (03): : 327 - &
[8] DIHYDROLIPOIC ACID - A UNIVERSAL ANTIOXIDANT BOTH IN THE MEMBRANE AND IN THE AQUEOUS PHASE - REDUCTION OF PEROXYL, ASCORBYL AND CHROMANOXYL RADICALS
KAGAN, VE
SHVEDOVA, A
SERBINOVA, E
KHAN, S
SWANSON, C
POWELL, R
PACKER, L
[J]. BIOCHEMICAL PHARMACOLOGY, 1992, 44 (08) : 1637 - 1649
[9] ALPHA-LIPOIC ACID SUPPLEMENTATION PREVENTS SYMPTOMS OF VITAMIN-E-DEFICIENCY
PODDA, M
TRITSCHLER, HJ
ULRICH, H
PACKER, L
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (01) : 98 - 104
[10] DIHYDROLIPOATE REDUCES NEURONAL INJURY AFTER CEREBRAL-ISCHEMIA
PREHN, JHM
KARKOUTLY, C
NUGLISCH, J
PERUCHE, B
KRIEGLSTEIN, J
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1992, 12 (01) : 78 - 87

← 1 2 →