A QUANTITATIVE CHROMATOGRAPHIC METHOD FOR DETERMINATION OF PURITY OF OXYTETRACYCLINE

被引：5

作者：

BAILEY, F

机构：

[1] Pharmaceutical Department, ICI Ltd, Pharmaceuticals Division, Macclesfield, Cheshire

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / S 21卷

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08345.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A chromatographic method for the determination of oxytetracycline is described, employing a hexane‐ethyl acetate‐pH 3·3 buffer partition system supported on Celite. Chromatographic separation is followed by measuring the absorbance of the eluate at 263 nm. The system enables the determination of oxytetracycline to be made in the presence of anhydro‐oxytetracycline, chlortetracycline, α‐ and β‐apo‐oxytetracycline, and epi‐oxytetracycline, the last three being the most likely contaminants of crude material. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：S40 / &