MECHANISMS OF BRONCHOCONSTRICTION AND OF THROMBOCYTOPENIA INDUCED BY COLLAGEN IN THE GUINEA-PIG

被引：23

作者：

VARGAFTIG, BB ^{[1
]}

LEFORT, J ^{[1
]}

JOSEPH, D ^{[1
]}

FOUQUE, F ^{[1
]}

机构：

[1] MERRELL INT,CTR RECH,F-67084 STRASBOURG,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 58卷 / 03期

关键词：

Anti-inflammatory drugs; Bronchoconstriction; Coagulation; Collagen; Complement; Platelets; Thromboxane A2;

D O I：

10.1016/0014-2999(79)90476-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Collagen injected to guinea pigs i.v. increased the pulmonary resistance to inflation (bronchoconstriction) and induced thrombocytopenia. Immune platelet depletion protected against the effect of collagen, and has been shown not to prevent bronchoconstriction induced by the prostaglandin/thromboxane A2 precursor arachidonic acid. Use of inhibitors demonstrated that histamine, serotonin, acetylcholine and bradykinin were not involved with the effects of collagen in the guinea pig. Aspirin and indomethacin inhibited collagen-induced bronchoconstriction completely and thrombocytopenia partly, supporting the hypothesis that the former is prostaglandin cyclo-oxygenase dependent, whereas the latter has a thromboxane A2-independent mechanism as well. Carrageenan, heparin and reserpine inhibited the in vivo effects of collagen to various extents, but their precise mechanism of action could not be discovered. Collagen-induced bronchoconstriction is strictly platelet and thromboxane A2-dependent. © 1979.

引用

页码：273 / 284

页数：12

共 45 条

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[2]

BENNER KU, 1975, ARZNEIMITTEL-FORSCH, V25, P1635

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