AUTOANTIBODIES TO GLYCOPROTEIN ANTIGENS MEDIATE SUBACUTE DEMYELINATING ENCEPHALOMYELITIS IN THE LEWIS RAT

被引：4

作者：

GAUTAM, AM

VOCCIA, I

MUNRO, PMG

NOLAN, C

BROWN, A

WYLIE, S

GLYNN, P

机构：

[1] MRC LABS,WOODMANSTERNE RD,CARSHALTON SM5 4EF,SURREY,ENGLAND

[2] INST NEUROL,MULTIPLE SCLEROSIS SOC LAB,LONDON WC1N 1PJ,ENGLAND

[3] INST NEUROL,MULTIPLE SCLEROSIS NMR RES GRP,LONDON WC1N 1PJ,ENGLAND

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 33卷 / 02期

关键词：

DEMYELINATION; AUTOANTIBODY; MYELIN GLYCOPROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS;

D O I：

10.1016/0165-5728(91)90055-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Serum autoantibodies were induced in Lewis rats by immunization with a mixture of lentil lectin-binding glycoproteins isolated from bovine brain myelin. Intraperitoneal administration of 2-10 million syngeneic myelin basic protein-activated spleen cells to these rats led within 4-5 days to paralysis which, in most cases, persisted for several weeks. The major neuropathological features of the disease were numerous macrophages in both brain and spinal cord and large areas of demyelination, generally with axon preservation, particularly adjacent to the pial surfaces of the cord. This model is easily induced and will be useful for studies of demyelination and remyelination.

引用

页码：113 / 120

页数：8

共 14 条

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[2]

MECHANISM OF DEMYELINATION IN THE GUINEA-PIG - SEPARATE SENSITIZATION WITH ENCEPHALITOGENIC MYELIN BASIC-PROTEIN AND NONENCEPHALITOGENIC BRAIN COMPONENTS [J].