OPTICALLY-ACTIVE COMPOUNDS VIA BIOCATALYTIC METHODS

被引：20

作者：

SIH, CJ

GU, QM

HOLDGRUN, X

HARRIS, K

机构：

[1] School of Pharmacy, University of Wisconsin, Madison

来源：

CHIRALITY | 1992年 / 4卷 / 02期

关键词：

IMPROVING ENANTIOSELECTIVITY; LIPASE; ENANTIOSELECTIVE BIOCATALYSIS; ENANTIOMERICALLY PURE COMPOUNDS; DIHYDROPYRIDINES; ENANTIOSELECTIVE INHIBITION; CIS-3-HYDROXY-6-ACETOXY-CYCLOHEX-1-ENE;

D O I：

10.1002/chir.530040205

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Different approaches to improve the enantioselectivity of biocatalytic systems are presented. These methodologies have been successfully applied to the preparation of optically active dihydropyridine, calcium antagonists, and cis-3-hydroxy-6-acetoxy-cyclohex-1-ene, a valuable chiral building block for natural products synthesis. The phenomenon of enantioselective inhibition is described and several new heterocyclic amines have been shown to be effective enantioselective inhibitors in the Candida lipase system.

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页码：91 / 97

页数：7

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