GENETIC-ANALYSIS OF HLA CLASS-II ALLELES AND SUSCEPTIBILITY TO TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN JAPANESE SUBJECTS

被引：133

作者：

AWATA, T ^{[1
]}

KUZUYA, T ^{[1
]}

MATSUDA, A ^{[1
]}

IWAMOTO, Y ^{[1
]}

KANAZAWA, Y ^{[1
]}

机构：

[1] JICHI MED SCH,OMIYA MED CTR,OMIYA,JAPAN

来源：

DIABETOLOGIA | 1992年 / 35卷 / 05期

关键词：

HUMAN LEUKOCYTE ANTIGEN (HLA); GENE; SUSCEPTIBILITY; TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS; JAPANESE;

D O I：

10.1007/BF02342437

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although HLA-DQB1 alleles encoding aspartic acid at position 57(Asp-57)are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele. We analysed the DRB1, DQA1 and DQB1 genes of 99 Japanese patients and 86 control subjects with polymerase chain reaction and sequence-specific oligonucleotide hybridization. We found that (1) the DQA1*0301 allele was significantly increased in Type 1 diabetic patients (RR 7.8, pc < 0.0001); (2) the DRB1*0405 (Dw15) allele, which is a subtype of DR4 haplotype, was significantly increased in DR4-positive patients (RR 12.0, pc < 0.001); and (3) although the DRw8-DQw8 haplotype was positively associated with Type 1 diabetes, the DRB1*0406-DQw8 haplotype was decreased in the diabetic patients. These data indicate that DRB1 and DQA1 genes also confer susceptibility to Type 1 diabetes in Japanese.

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收藏

页码：419 / 424

页数：6

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