ENANTIOSELECTIVE SYNTHESIS OF 5-SUBSTITUTED-2-FORMYLPYRROLIDINE AND 3,5-DISUBSTITUTED-2-FORMYLPYRROLIDINE DERIVATIVES, THE KEY D-RING FRAGMENTS OF (-)-QUINOCARCIN AND (-)-10-DECARBOXYQUINOCARCIN

被引：40

作者：

KATOH, T ^{[1
]}

NAGATA, Y ^{[1
]}

KOBAYASHI, Y ^{[1
]}

ARAI, K ^{[1
]}

MINAMI, J ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 36期

关键词：

QUINOCARCIN; 10-DECARBOXYQUINOCARCIN; D-RING FRAGMENT; 5-SUBSTITUTED-2-FORMYLPYRROLIDINE; 3,5-DISUBSTITUTED-2-FORMYLPYRROLIDINE;

D O I：

10.1016/S0040-4039(00)73849-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title synthesis was achieved starting from (S)-glutamic acid and (S)-pyroglutamic acid by featuring formation of an N-protected aminal, substitution of the methoxy group with cyanide anion, and reduction of the cyanide to an aldehyde as common key steps.

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页码：5743 / 5746

页数：4

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