IL-1-BETA-LIKE FREUNDS-ADJUVANT ENHANCES AXONAL-TRANSPORT OF OPIATE RECEPTORS IN SENSORY NEURONS

被引：24

作者：

JEANJEAN, AP ^{[1
]}

MALOTEAUX, JM ^{[1
]}

LADURON, PM ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN, ECOLE PHARM, B-1200 BRUSSELS, BELGIUM

来源：

NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期

关键词：

IL-1-BETA; AXONAL TRANSPORT; MU AND KAPPA OPIATE RECEPTOR; INFLAMMATION; PAIN; NOCICEPTOR;

D O I：

10.1016/0304-3940(94)90048-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic pain and inflammation increase substance P in sensory fibres of peripheral nerves in which opiate receptors are known to undergo axonal transport. The aim of the present study was to evaluate a possible modulation of axonal transport of opiate receptors in peripheral nerves during inflammation. After intraplantar injection of Freund's adjuvant to rats, the accumulation of mu and kappa opiate receptors increased on both sides of ligature in sciatic nerves of the injected paw. The contralateral side was unaffected and may serve as control. When IL-1 beta was injected into rat paws, the axonal transport of opiate receptors was increased in a similar way. This suggests that IL-1 beta represents a major mediator to sensitize nociceptors during inflammation through a process requiring retrograde signals.

引用

页码：75 / 78

页数：4

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