ANTIULCER EFFECT OF NARINGIN ON GASTRIC-LESIONS INDUCED BY ETHANOL IN RATS

被引：137

作者：

MARTIN, MJ ^{[1
]}

MARHUENDA, E ^{[1
]}

PEREZGUERRERO, C ^{[1
]}

FRANCO, JM ^{[1
]}

机构：

[1] UNIV SEVILLA, FAC QUIM, DEPT INGN QUIM, E-41071 SEVILLE, SPAIN

来源：

PHARMACOLOGY | 1994年 / 49卷 / 03期

关键词：

NARINGIN; FLAVONOIDS; GASTRIC PROTECTION; ETHANOL-INDUCED INJURY;

D O I：

10.1159/000139228

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study was designed to determine the gastroprotective properties of naringin on and the involvement of endogenous prostaglandins in mucosal injury produced by absolute ethanol. Oral pretreatment with the highest dose of naringin (400 mg/kg), 60 min before absolute ethanol was the most effective antiulcer treatment. Subcutaneous administration of indometacin (10 mg/kg) to the animals treated with naringin (400 mg/kg) partially inhibited gastric protection, but the prostaglandin E(2) determination did not show any increase in prostanoid levels. The contents of gastric mucus and total proteins were not significantly modified. Naringin-treated rats showed a marked increase in hexosamine levels, but this increase was less in animals pretreated with indometacin. These results show that naringin has a 'cytoprotective' effect against ethanol injury in the rat, but this property appears to be mediated by non-prostaglandin-dependent mechanisms.

引用

页码：144 / 150

页数：7

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