STRUCTURE-ACTIVITY STUDIES OF THE NATURAL PRODUCT SUBSTANCE-P ANTAGONIST WIN-64821

被引：29

作者：

BARROW, CJ

MUSZA, LL

COOPER, R

机构：

[1] Natural Products Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 04期

关键词：

D O I：

10.1016/0960-894X(95)00039-V

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tryptophyl alkylation at C3a of the diketopiperazine 2 gave compounds related to the substance P antagonist WIN 64821 (1). The biological activities of these compounds, and those of methyl analogs 13 and 14 produced by directed biosynthesis, gives structure-activity information for 1.

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页码：377 / 380

页数：4

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