EFFECTS OF THE ORNITHINE DECARBOXYLASE INHIBITORS DL-ALPHA-DIFLUOROMETHYLORNITHINE AND ALPHA-MONOFLUOROMETHYLDEHYDROORNITHINE METHYL-ESTER ALONE AND IN COMBINATION WITH SURAMIN AGAINST TRYPANOSOMA-BRUCEI-BRUCEI CENTRAL-NERVOUS-SYSTEM MODELS

被引:35
作者
BACCHI, CJ
NATHAN, HC
CLARKSON, AB
BIENEN, EJ
BITONTI, AJ
MCCANN, PP
SJOERDSMA, A
机构
[1] PACE UNIV,DEPT BIOL,NEW YORK,NY 10038
[2] NYU,DEPT MED & MOLEC PARASITOL,NEW YORK,NY 10016
[3] MERRELL DOW PHARMACEUT INC,RES INST,CINCINNATI,OH 45215
关键词
D O I
10.4269/ajtmh.1987.36.46
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
引用
收藏
页码:46 / 52
页数:7
相关论文
共 22 条
  • [1] POLYAMINE METABOLISM - A POTENTIAL THERAPEUTIC TARGET IN TRYPANOSOMES
    BACCHI, CJ
    NATHAN, HC
    HUTNER, SH
    [J]. SCIENCE, 1980, 210 (4467) : 332 - 334
  • [2] INVIVO EFFECTS OF ALPHA-DL-DIFLUOROMETHYLORNITHINE ON THE METABOLISM AND MORPHOLOGY OF TRYPANOSOMA-BRUCEI-BRUCEI
    BACCHI, CJ
    GAROFALO, J
    MOCKENHAUPT, D
    MCCANN, PP
    DIEKEMA, KA
    PEGG, AE
    NATHAN, HC
    MULLANEY, EA
    CHUNOSOFF, L
    SJOERDSMA, A
    HUTNER, SH
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1983, 7 (03) : 209 - 225
  • [3] BEY P, 1982, STRATEGY DRUG RES, P89
  • [4] UPTAKE OF ALPHA-DIFLUOROMETHYLORNITHINE BY TRYPANOSOMA-BRUCEI-BRUCEI
    BITONTI, AJ
    BACCHI, CJ
    MCCANN, PP
    SJOERDSMA, A
    [J]. BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) : 351 - 354
  • [5] CATALYTIC IRREVERSIBLE INHIBITION OF TRYPANOSOMA-BRUCEI-BRUCEI ORNITHINE DECARBOXYLASE BY SUBSTRATE AND PRODUCT ANALOGS AND THEIR EFFECTS ON MURINE TRYPANOSOMIASIS
    BITONTI, AJ
    BACCHI, CJ
    MCCANN, PP
    SJOERDSMA, A
    [J]. BIOCHEMICAL PHARMACOLOGY, 1985, 34 (10) : 1773 - 1777
  • [6] NEW DRUG-COMBINATION FOR EXPERIMENTAL LATE-STAGE AFRICAN TRYPANOSOMIASIS - DL-ALPHA-DIFLUOROMETHYLORNITHINE (DFMO) WITH SURAMIN
    CLARKSON, AB
    BIENEN, EJ
    BACCHI, CJ
    MCCANN, PP
    NATHAN, HC
    HUTNER, SH
    SJOERDSMA, A
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1984, 33 (06) : 1073 - 1077
  • [7] EFFICACY OF COMBINATIONS OF DIFLUOROMETHYLORNITHINE AND BLEOMYCIN IN A MOUSE MODEL OF CENTRAL NERVOUS-SYSTEM AFRICAN TRYPANOSOMIASIS
    CLARKSON, AB
    BACCHI, CJ
    MELLOW, GH
    NATHAN, HC
    MCCANN, PP
    SJOERDSMA, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (18): : 5729 - 5733
  • [8] MORPHOLOGICAL-CHANGES IN TRYPANOSOMA-BRUCEI-RHODESIENSE FOLLOWING INHIBITION OF POLYAMINE BIOSYNTHESIS INVIVO
    DEGEE, ALW
    CARSTENS, PHB
    MCCANN, PP
    MANSFIELD, JM
    [J]. TISSUE & CELL, 1984, 16 (05) : 731 - 738
  • [9] POLYAMINE DEPLETION FOLLOWING EXPOSURE TO DL-ALPHA-DIFLUOROMETHYLORNITHINE BOTH INVIVO AND INVITRO INITIATES MORPHOLOGICAL ALTERATIONS AND MITOCHONDRIAL ACTIVATION IN A MONOMORPHIC STRAIN OF TRYPANOSOMA-BRUCEI-BRUCEI
    GIFFIN, BF
    MCCANN, PP
    BITONTI, AJ
    BACCHI, CJ
    [J]. JOURNAL OF PROTOZOOLOGY, 1986, 33 (02): : 238 - 243
  • [10] Jennings F W, 1983, Contrib Microbiol Immunol, V7, P147