ADRENERGIC PARTICIPATION SUBSERVING A POSITIVE INOTROPISM AND CHRONOTROPISM OF PROSTACYCLIN ON ISOLATED RAT ATRIA

被引：18

作者：

BORDA, LS

CANGAS, L

GIMENO, MF

GIMENO, AL

机构：

[1] Centro de Estudios Farmacológicos y de Principios Naturales, Consejo Nacional de Investigaciones Científicas y Técnicas, de la República Argentina, Buenos Aires, 1428

来源：

EXPERIENTIA | 1979年 / 35卷 / 04期

关键词：

D O I：

10.1007/BF01922751

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effects of prostacyclin (PGI2) on the contractile frequency and on the isometric developed tension of spontaneously beating or paced isolated rat atria were explored. PGI2 enhanced frequency and contractile tension, both effects being blocked by the presence of propranolol, or following a pretreatment with 6-OHDopamine. © 1979 Birkhäuser Verlag.

引用

页码：529 / 530

页数：2

共 19 条

[1] COMPARISON OF VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6-OXO-PROSTAGLANDIN F-1-ALPHA WITH THOSE OF PROSTAGLANDIN-E2 IN RATS AND RABBITS [J].

ARMSTRONG, JM ;

LATTIMER, N ;

MONCADA, S ;

VANE, JR .

BRITISH JOURNAL OF PHARMACOLOGY, 1978, 62 (01) :125-130

[2] RELEASE OF A CORONARY VASODILATOR METABOLITE FROM GUINEA-PIG ISOLATED PERFUSED HEART STIMULATED BY CATECHOLAMINES, HISTAMINE AND ELECTRICAL PACING AND BY EXPOSURE TO ANOXIA [J].

BROADLEY, KJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1976, 58 (01) :89-100

[3] ARTERIAL-WALLS GENERATE FROM PROSTAGLANDIN ENDOPEROXIDES A SUBSTANCE (PROSTAGLANDIN-X) WHICH RELAXES STRIPS OF MESENTERIC AND CELIAC ARTERIES AND INHIBITS PLATELET-AGGREGATION [J].

BUNTING, S ;

GRYGLEWSKI, R ;

MONCADA, S ;

VANE, JR .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (06) :897-913

[4] PROSTACYCLIN IS MAJOR PROSTAGLANDIN RELEASED FROM ISOLATED PERFUSED RABBIT AND RAT-HEART [J].

DEDECKERE, EAM ;

NUGTEREN, DH ;

HOOR, FT .

NATURE, 1977, 268 (5616) :160-163

[5] PROSTACYCLIN (PGX) IS ENDOGENOUS METABOLITE RESPONSIBLE FOR RELAXATION OF CORONARY-ARTERIES INDUCED BY ARACHIDONIC-ACID [J].

DUSTING, GJ ;

MONCADA, S ;

VANE, JR .

PROSTAGLANDINS, 1977, 13 (01) :3-15

[6] CORONARY ARTERIAL SMOOTH-MUSCLE CONTRACTION BY A SUBSTANCE RELEASED FROM PLATELETS - EVIDENCE THAT IT IS THROMBOXANE-A2 [J].

ELLIS, EF ;

OELZ, O ;

ROBERTS, LJ ;

PAYNE, NA ;

SWEETMAN, BJ ;

NIES, AS ;

OATES, JA .

SCIENCE, 1976, 193 (4258) :1135-1137

[7]

GIMENO AL, 1966, MOL PHARMACOL, V21, P177

[8]

GOLDMAN H, 1971, J PHARMACOL EXP THER, V176, P119

[9] CELLULAR MEMBRANE POTENTIALS AND CONTRACTILITY OF NORMAL RAT ATRIUM AND THE EFFECTS OF TEMPERATURE, TENSION AND STIMULUS FREQUENCY [J].

HOLLANDER, PB ;

WEBB, JL .

CIRCULATION RESEARCH, 1955, 3 (06) :604-612

[10]

KARMAZYN M, 1977, IRCS (International Research Communications System) Medical Science Library Compendium, V5, P565

← 1 2 →