EVIDENCE THAT THE 5-HT1A RECEPTOR AGONISTS BUSPIRONE AND IPSAPIRONE ACTIVATE ADRENALINE RELEASE IN THE CONSCIOUS RAT

被引：39

作者：

CHAOULOFF, F

BAUDRIE, V

LAUDE, D

机构：

[1] Laboratoire de Pharmacologie, Groupe de Neuropharmacologie, INSERM U7

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 177卷 / 1-2期

关键词：

5-HT[!sub]1A[!/sub] receptors; Adrenaline; Buspirone; Glycemia; Ipsapirone;

D O I：

10.1016/0014-2999(90)90558-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to investigate the effects of the 5-HT1A receptor agonists buspirone and ipsapirone (1-10 mg/kg) on plasma adrenaline (A) levels and on glycemia in the conscious rat. The results indicate that buspirone was able, within 5 min, to increase plasma A and glucose levels in a dose-dependent manner. Ipsapirone administration triggered similar patterns, except that the highest dose used (10 mg/kg) promoted a time-dependent increase in plasma A and glucose levels that was maximal at the end of analysis. © 1990.

引用

页码：107 / 110

页数：4

共 10 条

[1] MARKED INCREASES IN PLASMA-CATECHOLAMINE CONCENTRATIONS PRECEDE HYPOTENSION AND BRADYCARDIA CAUSED BY 8-HYDROXY-2-(DI-N-PROPYLAMINO) TETRALIN (8-OH-DPAT) IN CONSCIOUS RATS [J].