ANTIVIRAL AGENTS - SYNTHESIS OF FURYLPYRIMIDINONES AND EVALUATION OF THEIR CYTOSTATIC AND ANTIVIRAL ACTIVITY

被引:8
作者
BOTTA, M
DEANGELIS, F
CORELLI, F
MENICHINCHERI, M
NICOLETTI, R
MARONGIU, ME
PANI, A
LACOLLA, P
机构
[1] UNIV LA SAPIENZA,DIPARTIMENTO CHIM ORGAN,I-00185 ROME,ITALY
[2] UNIV CAGLIARI,DIPARTIMENTO BIOL SPERIMENTALE,I-09124 CAGLIARI,ITALY
关键词
D O I
10.1002/ardp.19913240403
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Condensation between furyllithium reagents and pyrimidinones 1, 2, 3, and 4 has been studied. The product composition is strongly dependent upon the reaction conditions and purification methodologies. Cytostatic and antiviral activities of some substrates and reaction products is reported.
引用
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页码:203 / 207
页数:5
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