DOPAMINE AUTOSYNAPTIC AND POSTSYNAPTIC RECEPTORS - ELECTRO-PHYSIOLOGICAL EVIDENCE FOR DIFFERENTIAL SENSITIVITY TO DOPAMINE AGONISTS

被引：491

作者：

SKIRBOLL, LR ^{[1
]}

GRACE, AA ^{[1
]}

BUNNEY, BS ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT PHARMACOL, NEW HAVEN, CT 06510 USA

来源：

SCIENCE | 1979年 / 206卷 / 4414期

关键词：

D O I：

10.1126/science.482929

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The responses of dopamine cells in the substantia nigra to iontophoretically administered dopamine and intravenous apomorphine were compared to the responses of spontaneously active neurons in the caudate nucleus. Dopaminergic cells were six to ten times more sensitive to dopamine and intravenous apomorphine than 86 percent of the caudate cells tested. This differential sensitivity of dopamine auto- and postsynaptic receptors may explain the apparently paradoxical behavioral effects induced by small compared to large doses of some dopamine agonists and may provide a means of developing new types of drugs to antagonize dopaminergic influence in the central nervous system. Copyright © 1979 AAAS.

引用

页码：80 / 82

页数：3

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