DISCORDANCE AND CONCORDANCE OF DEMENTIA OF THE ALZHEIMER TYPE (DAT) IN MONOZYGOTIC TWINS INDICATE HERITABLE AND SPORADIC FORMS OF ALZHEIMERS-DISEASE

Monozygotic (MZ) twin pairs concordant for dementia of the Alzheimer type (DAT) or for proven Alzheimer's disease (AD) have a significantly higher frequency of a positive family history (DAT or AD in at least one first-degree relative, p < 0.002) than do discordant MZ twin pairs, consistent with a lesser predicted distribution of proportions of surviving first-degree relatives without DAT (or AD) (p < 0.001). The results suggest that concordant MZ twin pairs with DAT (or AD) have a heritable form of disease. AD in discordant twins may result from environmental influences or from a somatic chromosomal change following zygotic division.