DISCORDANCE AND CONCORDANCE OF DEMENTIA OF THE ALZHEIMER TYPE (DAT) IN MONOZYGOTIC TWINS INDICATE HERITABLE AND SPORADIC FORMS OF ALZHEIMERS-DISEASE

被引:36
作者
RAPOPORT, SI [1 ]
PETTIGREW, KD [1 ]
SCHAPIRO, MB [1 ]
机构
[1] NIMH,DIV BIOMETRY & APPL SCI,BETHESDA,MD 20892
关键词
D O I
10.1212/WNL.41.10.1549
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Monozygotic (MZ) twin pairs concordant for dementia of the Alzheimer type (DAT) or for proven Alzheimer's disease (AD) have a significantly higher frequency of a positive family history (DAT or AD in at least one first-degree relative, p < 0.002) than do discordant MZ twin pairs, consistent with a lesser predicted distribution of proportions of surviving first-degree relatives without DAT (or AD) (p < 0.001). The results suggest that concordant MZ twin pairs with DAT (or AD) have a heritable form of disease. AD in discordant twins may result from environmental influences or from a somatic chromosomal change following zygotic division.
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页码:1549 / 1553
页数:5
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