MYCINAMICIN BIOSYNTHESIS - ISOLATION AND STRUCTURAL ELUCIDATION OF MYCINONIC ACIDS, PROPOSED INTERMEDIATES FOR FORMATION OF MYCINAMICINS - X-RAY MOLECULAR-STRUCTURE OF PARA-BROMOPHENACYL 5-HYDROXY-4-METHYLHEPT-2-ENOATE

被引：14

作者：

KINOSHITA, K ^{[1
]}

TAKENAKA, S ^{[1
]}

HAYASHI, M ^{[1
]}

机构：

[1] TOYO JOZO CO LTD,DEV DIV FERMENTAT TECHNOL,OHITO,SHIZUOKA 41023,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 10期

关键词：

D O I：

10.1039/p19910002547

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mycinonic acids, proposed intermediates in the biosynthesis of the macrolide antibiotic mycinamicins, were isolated from the culture filtrate of Micromonospora griseorubida and their chemical structures were determined on the basis of their spectroscopic data. Their absolute configurations were confirmed by X-ray diffraction analysis and comparison of their total syntheses. Their possible role in the biosynthesis of mycinamicins is discussed.

引用

页码：2547 / 2554

页数：8

共 19 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2] MACROLIDE BIOSYNTHESIS .4. INTACT INCORPORATION OF A CHAIN-ELONGATION INTERMEDIATE INTO ERYTHROMYCIN [J].

CANE, DE ;

YANG, CC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (04) :1255-1257

[3]

CORCORAN JW, 1984, ANTIBIOTICS, V4, P132

[4] MYCINAMICINS, NEW MACROLIDE ANTIBIOTICS .5. ISOLATION AND STRUCTURES OF NEW 16-MEMBERED AGLYCONES, MYCINOLIDE-IV AND PROTOMYCINOLIDE-IV [J].

HAYASHI, M ;

OHARA, H ;

OHNO, M ;

SAKAKIBARA, H ;

SATOI, S ;

HARADA, KI ;

SUZUKI, M .

JOURNAL OF ANTIBIOTICS, 1981, 34 (08) :1075-1077

[5] STRUCTURES OF MYCINAMICINS [J].

HAYASHI, M ;

OHNO, M ;

SATOI, S .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1980, (03) :119-121

[6] MYCINAMICINS, NEW MACROLIDE ANTIBIOTICS .4. STRUCTURE OF MYCINAMICIN-III [J].

HAYASHI, M ;

OHNO, M ;

KATSUMATA, S ;

SATOI, S ;

HARADA, KI ;

TAKEDA, M ;

SUZUKI, M .

JOURNAL OF ANTIBIOTICS, 1981, 34 (03) :276-281

[7] MYCINAMICINS, NEW MACROLIDE ANTIBIOTICS .7. STRUCTURES OF MINOR COMPONENTS, MYCINAMICIN-VI AND MYCINAMICIN-VII [J].

HAYASHI, M ;

KINOSHITA, K ;

SUDATE, Y ;

SATOI, S ;

SAKAKIBARA, H ;

HARADA, K ;

SUZUKI, M .

JOURNAL OF ANTIBIOTICS, 1983, 36 (02) :175-178

[8] MYCINAMICINS, NEW MACROLIDE ANTIBIOTICS .8. CHEMICAL DEGRADATION AND ABSOLUTE-CONFIGURATION OF MYCINAMICINS [J].

KINOSHITA, K ;

SATOI, S ;

HAYASHI, M ;

HARADA, K ;

SUZUKI, M ;

NAKATSU, K .

JOURNAL OF ANTIBIOTICS, 1985, 38 (04) :522-526

[9] MYCINAMICINS, NEW MACROLIDE ANTIBIOTICS .11. ISOLATION AND STRUCTURE ELUCIDATION OF A KEY INTERMEDIATE IN THE BIOSYNTHESIS OF THE MYCINAMICINS, MYCINAMICIN-VIII [J].

KINOSHITA, K ;

IMURA, Y ;

TAKENAKA, S ;

HAYASHI, M .

JOURNAL OF ANTIBIOTICS, 1989, 42 (12) :1869-1872

[10] ISOLATION OF PROPOSED INTERMEDIATES IN THE BIOSYNTHESIS OF MYCINAMICINS [J].

KINOSHITA, K ;

TAKENAKA, S ;

HAYASHI, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (14) :943-945

← 1 2 →