PERVASIVE CPG SUPPRESSION IN ANIMAL MITOCHONDRIAL GENOMES

被引：202

作者：

CARDON, LR ^{[1
]}

BURGE, C ^{[1
]}

CLAYTON, DA ^{[1
]}

KARLIN, S ^{[1
]}

机构：

[1] STANFORD UNIV,SCH MED,DEPT DEV BIOL,STANFORD,CA 94035

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 09期

关键词：

D O I：

10.1073/pnas.91.9.3799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

All available complete mitochondrial genomes (21 species) are evaluated for dinucleotide over- and under-representation. The CpG dinucleotide is pervasively under-represented in all animal mitochondria, but it is of variable relative abundance in fungal, protist, and plant mitochondrial genomes. Interpretations and hypotheses are considered relative to mitochondrial genome organization, methylation, structural specificities, directed mutation, and evolutionary events. In particular, our results support Mycoplasma capricolum or a close relative as the most likely bacterial ancestor of the mitochondria.

引用

页码：3799 / 3803

页数：5

共 24 条

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