INTERRELATION BETWEEN ANGIOGRAPHIC SEVERITY OF CORONARY-ARTERY DISEASE AND PLASMA-LEVELS OF INSULIN, C-PEPTIDE AND PLASMINOGEN-ACTIVATOR INHIBITOR-1

被引:44
作者
NEGRI, M
SHEIBAN, I
ARIGLIANO, PL
TONNI, S
MONTRESOR, G
CARLINI, S
MANZATO, F
机构
[1] UNIV VERONA,IST CLIN MED,CTR FISIOPATOL CARDIOCIRCOLATORIA,I-37100 VERONA,ITALY
[2] UNIV VERONA,IST CHIM & MICROSCOPIA CLIN,I-37100 VERONA,ITALY
关键词
D O I
10.1016/0002-9149(93)91129-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Plasma insulin, C-peptide and plasminogen activator inhibitor-1 (PAI-1) levels were. measured in 64 men with coronary artery disease (CAD) documented by angiography. Coronary arteriograms were analyzed, and the severity and diffusion of coronary lesions were quantified by score systems. C-peptide and PAI-1 levels in patients with CAD were significantly higher than in 30 control subjects. Insulin, C-peptide and PAI-1 showed a highly significant correlation with the severity scores for coronary lesions (C-peptide more than insulin), but only a weak correlation with diffusion scores. Highly significant correlations were found between insulin and PAI-1, and even greater ones between C-peptide and PAI-1. It has been proposed that hyperinsulinemia may be involved in the etiology of atherosclerotic cardiovascular disease by dysregulating lipoprotein metabolism and blood pressure. These findings support that hypothesis and suggest that insulin secretion may be an index of the severity of CAD. Because a direct effect of insulin on the cells that synthesize PAI-1 has been shown, the present data further indicate that the effect of insulin on fibrinolysis may be another way by which hyperinsulinemia accelerates atherogenesis.
引用
收藏
页码:397 / 401
页数:5
相关论文
共 29 条
[21]   LIPOPROTEIN PREDICTORS OF THE SEVERITY OF CORONARY-ARTERY DISEASE IN MEN AND WOMEN [J].
REARDON, MF ;
NESTEL, PJ ;
CRAIG, IH ;
HARPER, RW .
CIRCULATION, 1985, 71 (05) :881-888
[22]   ROLE OF INSULIN RESISTANCE IN HUMAN-DISEASE [J].
REAVEN, GM .
DIABETES, 1988, 37 (12) :1595-1607
[23]   CLINICAL-SIGNIFICANCE OF PLASMINOGEN-ACTIVATOR INHIBITOR ACTIVITY IN PATIENTS WITH EXERCISE-INDUCED ISCHEMIA [J].
SAKATA, K ;
KURATA, C ;
TAGUCHI, T ;
SUZUKI, S ;
KOBAYASHI, A ;
YAMAZAKI, N ;
RYDZEWSKI, A ;
TAKADA, Y ;
TAKADA, A .
AMERICAN HEART JOURNAL, 1990, 120 (04) :831-838
[24]   RADIOIMMUNOASSAY MAY OVERESTIMATE INSULIN IN NON-INSULIN-DEPENDENT DIABETICS [J].
TEMPLE, RC ;
CLARK, PMS ;
NAGI, DK ;
SCHNEIDER, AE ;
YUDKIN, JS ;
HALES, CN .
CLINICAL ENDOCRINOLOGY, 1990, 32 (06) :689-693
[25]  
VAGUE P, 1987, THROMB HAEMOSTASIS, V57, P326
[26]   CORRELATION BETWEEN BLOOD FIBRINOLYTIC-ACTIVITY, PLASMINOGEN-ACTIVATOR INHIBITOR LEVEL, PLASMA-INSULIN LEVEL, AND RELATIVE BODY-WEIGHT IN NORMAL AND OBESE SUBJECTS [J].
VAGUE, P ;
JUHANVAGUE, I ;
AILLAUD, MF ;
BADIER, C ;
VIARD, R ;
ALESSI, MC ;
COLLEN, D .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1986, 35 (03) :250-253
[27]  
Welborn T A, 1979, Diabetes Care, V2, P154, DOI 10.2337/diacare.2.2.154
[28]   RELATION OF BODY-FAT DISTRIBUTION IN MEN AND DEGREE OF CORONARY NARROWINGS IN CORONARY-ARTERY DISEASE [J].
ZAMBONI, M ;
ARMELLINI, F ;
SHEIBAN, I ;
DEMARCHI, M ;
TODESCO, T ;
BERGAMOANDREIS, IA ;
COMINACINI, L ;
BOSELLO, O .
AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (13) :1135-1138
[29]   RISK-FACTORS FOR CORONARY-ARTERY DISEASE IN HEALTHY-PERSONS WITH HYPERINSULINEMIA AND NORMAL GLUCOSE-TOLERANCE [J].
ZAVARONI, I ;
BONORA, E ;
PAGLIARA, M ;
DALLAGLIO, E ;
LUCHETTI, L ;
BUONANNO, G ;
BONATI, PA ;
BERGONZANI, M ;
GNUDI, L ;
PASSERI, M ;
REAVEN, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (11) :702-706