CHARGE DISPLACEMENT INDUCED BY RAPID STRETCH IN THE BASOLATERAL MEMBRANE OF THE GUINEA-PIG OUTER HAIR CELL

被引:102
作者
GALE, JE
ASHMORE, JF
机构
[1] Department of Physiology, School of Medical Sciences, Bristol BS8 1TD, University Walk
关键词
D O I
10.1098/rspb.1994.0035
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The properties of the basolateral membrane of cochlear outer hair cells were studied under whole-cell patch clamp to measure currents and capacitance changes associated with mechanical deformation. Stretching the membrane of outer hair cells along the cell axis generated a transient inward current, and subsequent relaxation of the membrane produced a similar transient outward current. These mechanically activated currents were velocity dependent with a mean sensitivity of 29 pA s mm-1. Unlike ionic currents, these currents did not reverse, but reached a peak magnitude at -33 mV. Stretching the cell also resulted in a measurable capacitance decrease of 0.3-1.1 pF mum-1. These results suggest that membrane stretch can induce a rapid charge movement resulting from the reversal of the electromechanical transduction process in outer hair cells.
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页码:243 / 249
页数:7
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