ESOPHAGEAL CANCER AND AMPLIFICATION OF THE HUMAN CYCLIN-D GENE CCND1/PRAD1

被引：85

作者：

ADELAIDE, J

MONGES, G

DERDERIAN, C

SEITZ, JF

BIRNBAUM, D

机构：

[1] INSERM, U119, F-13009 MARSEILLE, FRANCE

[2] INST J PAOLI I CALMETTES, BIOL TUMEURS LAB, F-13009 MARSEILLE, FRANCE

[3] INST J PAOLI I CALMETTES, DEPT ANAT PATHOL, MARSEILLE, FRANCE

[4] INST J PAOLI I CALMETTES, DEPT ONCOL DIGEST, MARSEILLE, FRANCE

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 01期

关键词：

ESOPHAGEAL CANCER; CYCLIN; CHROMOSOME; 11; AMPLIFICATION; ONCOGENE;

D O I：

10.1038/bjc.1995.13

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The human CCND1/PRAD1 gene, located in the 11q13 chromosomal region, encodes a cyclin D protein with potential oncogenic capacity and is involved in several human malignancies. The amplification and expression status of CCND1 was investigated in a series of oesophageal tumours. CCND1 is amplified in 54% and overexpressed in 63% of the tumours of the squamous cell type.

引用

页码：64 / 68

页数：5

共 49 条

[1]

ADELAIDE J, 1988, ONCOGENE, V2, P413

[2]

BALE AE, 1991, CANCER RES, V51, P1154

[3] GENE AMPLIFICATION AND TUMOR PROGRESSION [J].