METABOLIC SUICIDE GENES IN GENE-THERAPY

被引：93

作者：

MULLEN, CA ^{[1
]}

机构：

[1] NCI,DIV CANC BIOL DIAG & CTR,METAB BRANCH,BETHESDA,MD 20892

来源：

PHARMACOLOGY & THERAPEUTICS | 1994年 / 63卷 / 02期

基金：

美国国家卫生研究院;

关键词：

SUICIDE GENE; GENE THERAPY; THYMIDINE KINASE; CYTOSINE DEAMINASE; RETROVIRUS; TRANSFECTION; GANCICLOVIR;

D O I：

10.1016/0163-7258(94)90046-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article reviews uses of metabolic suicide genes in gene therapy. Suicide genes encode novel nonmammalian enzymes that can convert a relatively nontoxic prodrug into a highly toxic agent. Cells genetically transduced to express such genes essentially commit metabolic suicide in the presence of the appropriate prodrug. Three metabolic suicide genes are described: herpes simplex thymidine kinase, Escherichia coli cytosine deaminase and varicella tester thymidine kinase. Transfer and expression of these genes into mammalian cells is described. Preclinical models of suicide gene therapy of cancer and human immunodeficiency virus are discussed, and several clinical trials employing suicide genes are described.

引用

页码：199 / 207

页数：9

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