EFFECT OF DICHLORVOS ON EMBRYONAL AND FETAL DEVELOPMENT IN THYROPARATHYROIDECTOMIZED, THYROXINE-TREATED AND EUTHYROID RATS

被引：5

作者：

BAKSI, SN ^{[1
]}

机构：

[1] NIEHS,ENVIRONM TOXICOL BRANCH,RES TRIANGLE PK,NC 27709

来源：

TOXICOLOGY LETTERS | 1978年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0378-4274(78)90069-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Dichlorvos was administered (25 mg /kg/day) by gavage to previously thyroparathyroidectomized (TPTX), thyroxine (T4)-treated and intact saline treated rats from day 8 through 15 gestation. Dichlorvos treatment during gestation reduced the maternal body weight gain in all groups but was significant (P < 0.05) only in the T4-treated group. TPTX alone adversely affected maternal body weight gain before and after gestation, implantation, litter size and fetal weight. Placental weight was significantly (P < 0.05) lower in the oil-treated intact control group only. No significant difference was found in gross, visceral and skeletal anomalies of the fetuses in any group. © 1978.

引用

页码：213 / 216

页数：4

共 10 条

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