EFFICIENT AND CONVENIENT SYNTHESIS OF 5-(3,3-DIMETHYL-C-14-1-TRIAZENO)-IMIDAZOLE-4-CARBOXAMIDE

被引：1

作者：

FARQUHAR, D

BENVENUTO, JA

LOO, TL

机构：

[1] Department of Developmental Therapeutics, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 04期

关键词：

5‐(3,3‐Dimethyl‐<sup>14</sup>C‐1‐triazeno)imidazole‐4‐carboxamide; 5‐diazoimidazole‐4‐carboxamide; Dacarbazine; DTIC;

D O I：

10.1002/jlcr.2580160414

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Reaction of dimethylamine‐14C with a four‐fold molar excess of 5‐doazoimidazole‐4‐carboxamide in methanol followed by column chromatography of the product on basic alumina afforded 5‐(3,3‐dimethyl‐14C‐1‐triazeno)imidazole‐4‐carboxamide in 70–75% yield and greater than 99.9% radiochemical purity. The preparation is suitable for chemical and biological mechanistic studies. Copyright © 1979 John Wiley & Sons, Ltd.

引用

页码：615 / 622

页数：8

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[9]

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