AGING - EFFECTS ON CHRONOTROPIC ACTIONS OF MUSCARINIC AGONISTS IN ISOLATED RAT ATRIA

被引：13

作者：

KENNEDY, RH ^{[1
]}

SEIFEN, E ^{[1
]}

机构：

[1] UNIV ARKANSAS MED SCI HOSP, DEPT PHARMACOL & INTERDISCIPLINARY TOXICOL, LITTLE ROCK, AR 72205 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1990年 / 51卷 / 01期

关键词：

Acetylcholinesterase; Aging; Chronotropic effects; Fischer; 344; rats; Muscarinic agonists;

D O I：

10.1016/0047-6374(90)90164-B

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Negative chronotropic effects of acetylcholine and carbachol were compared in right atria isolated from adult and aged Fischer 344 rats. Preparations from aged rats were more sensitive to the action of acetylcholine; however, there was no difference in responsiveness to carbachol or to acetylcholine after pretreatment with diisopropylfluorophosphate, an irreversible cholinesterase inhibitor. These data suggest that the enhanced sensitivity to the direct chronotropic action of acetylcholine is the result of aging-related reductions in acetylcholinestrase activity. © 1990.

引用

页码：81 / 87

页数：7

共 12 条

[1] AGE-RELATED-CHANGES IN CARDIAC MUSCARINIC RECEPTORS - DECREASED ABILITY OF THE RECEPTOR TO FORM A HIGH-AFFINITY AGONIST BINDING STATE [J].