HEAVY-CHAIN OF HUMAN HISTOCOMPATIBILITY ANTIGEN HLA-B7 CONTAINS AN IMMUNOGLOBULIN-LIKE REGION

被引：131

作者：

ORR, HT

LANCET, D

ROBB, RJ

LOPEZDECASTRO, JA

STROMINGER, JL

机构：

[1] Harvard University, Biological Laboratories, Cambridge

来源：

NATURE | 1979年 / 282卷 / 5736期

关键词：

D O I：

10.1038/282266a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 88-residue fragment (ac-2) containing the second disulphide loop from HLA-B7 heavy chain is shown to have statistically significant homology with Ig constant domains, including both matches at invariant positions and conservative substitutions of structurally important residues. Thus, both the light chain (β2m) and a segment of the heavy chain of HLA antigens may be structurally and evolutionarily related to immunoglobulins. © 1979 Nature Publishing Group.

引用

页码：266 / 270

页数：5

共 46 条

[1] GENETICS OF TRANSPLANTATION - MAJOR HISTOCOMPATIBILITY COMPLEX [J].