HISTOPATHOLOGIC CORRELATION OF MAGNETIC-RESONANCE-IMAGING SIGNAL PATTERNS IN A SPINAL-CORD INJURY MODEL

被引：96

作者：

WEIRICH, SD ^{[1
]}

COTLER, HB ^{[1
]}

NARAYANA, PA ^{[1
]}

HAZLE, JD ^{[1
]}

JACKSON, EF ^{[1
]}

COUPE, KJ ^{[1
]}

MCDONALD, CL ^{[1
]}

LANGFORD, LA ^{[1
]}

HARRIS, JH ^{[1
]}

机构：

[1] TEXAS BACK INST,2000 CRAWFORD,HOUSTON,TX 77002

来源：

SPINE | 1990年 / 15卷 / 07期

关键词：

Histopathology; Magnetic resonance imaging; Rat model; Spinal cord injury;

D O I：

10.1097/00007632-199007000-00004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Magnetic resonance imaging (MRI) provides a noninva- sive method of monitoring the pathologic response to spinal cord injury. Specific MR signal intensity patterns appear to correlate with degrees of improvement in the neurologic status in spinal cord injury patients. Histologic correlation of two types of MR signal intensity patterns are confirmed in the current study using a rat animal model. Adult male Sprague-Dawley rats underwent spinal cord trauma at the midthoracic level using a weight-dropping technique. After laminectomy, 5- and 10-gm brass weights were dropped from designated heights onto a 0.1-gm impounder placed on the exposed dura. Animals allowed to regain consciousness demonstrated variable recovery of hind limb paraplegia. Magnetic resonance images were obtained from 2 hours to 1 week after injury using a 2-tesla MRI/spectrometer. Sacrifice under anesthesia was performed by perfusive fixation; spinal columns were excised en bloc, embedded, sectioned, and observed with the compound light microscope. Magnetic resonance axial images obtained during the time sequence after injury demonstrate a distinct correlation between MR signal intensity patterns and the histologic appearance of the spinal cord. Magnetic resonance imaging delineates the pathologic processes resulting from acute spinal cord injury and can be used to differentiate the type of injury and prognosis. © Lippincott-Raven Publishers.

引用

页码：630 / 638

页数：9

共 50 条

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