VALIDATION OF AN EXPERT SYSTEM FOR THE SELECTION OF INITIAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC CONDITIONS FOR THE ANALYSIS OF BASIC DRUGS

被引：17

作者：

MARIS, F ^{[1
]}

HINDRIKS, R ^{[1
]}

VINK, J ^{[1
]}

PEETERS, A ^{[1
]}

VANDENDRIESSCHE, N ^{[1
]}

MASSART, L ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSELS,INST PHARMACEUT,B-1090 BRUSSELS,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 506卷

关键词：

D O I：

10.1016/S0021-9673(01)91579-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A prototype expert system was built which gives advice on the liquid chromatographic conditions for the analysis of basic compounds. In the validation process, the correct implementation of the knowledge and the advice of the expert system on real samples has been checked. For more than 50 compounds, the consultation of the expert system resulted in 75% correct proposals. Rules have been implemented to guide the operator in case the first proposal results in retention times that are not in the desired range. © 1990.

引用

页码：211 / 221

页数：11

共 14 条

[1] EXPERT SYSTEM FOR THE SELECTION OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHODS IN PHARMACEUTICAL ANALYSIS - VALIDATION OF THE RULES FOR THE SELECTION OF THE MOBILE PHASE
DESMET, M
PEETERS, A
BUYDENS, L
MASSART, DL
[J]. JOURNAL OF CHROMATOGRAPHY, 1988, 457 : 25 - 42
[2] DOLAN JW, 1989, PITTSBURGH C ANAL CH
[3] DESIGN AND APPLICATION OF AN EXPERT SYSTEM FOR MOBILE PHASE OPTIMIZATION IN REVERSED-PHASE LIQUID-CHROMATOGRAPHY
FELL, AF
BRIDGE, TP
WILLIAMS, MH
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1988, 6 (6-8) : 555 - 564
[4] EXPERT SYSTEMS FOR CHEMICAL-ANALYSIS (ESPRIT PROJECT 1570)
GOULDER, D
BLAFFERT, T
BLOKLAND, A
BUYDENS, L
CHHABRA, A
CLELAND, A
DUNAND, N
HINDRIKS, H
KATEMAN, G
VANLEEUWEN, H
MASSART, D
MULHOLLAND, M
MUSCH, G
NAISH, P
PEETERS, A
POSTMA, G
SCHOENMAKERS, P
DESMET, M
VANDEGINSTE, B
VINK, J
[J]. CHROMATOGRAPHIA, 1988, 26 : 237 - 243
[5] EXPERT SYSTEM FOR THE SELECTION OF INITIAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC CONDITIONS FOR THE ANALYSIS OF PHARMACEUTICALS
HINDRIKS, R
MARIS, F
VINK, J
PEETERS, A
DESMET, M
MASSART, DL
BUYDENS, L
[J]. JOURNAL OF CHROMATOGRAPHY, 1989, 485 : 255 - 265
[6] HODGES RS, 1989, PITTSBURGH C ANAL CH
[7] Kaliszan R., 1987, QUANTITATIVE STRUCTU
[8] KIRKLAND JJ, 1989, PITTSBURGH C ANAL CH
[9] AN EXPERT SYSTEM FOR THE SELECTION OF CRITERIA FOR SELECTIVITY OPTIMIZATION IN HIGH-PRESSURE LIQUID-CHROMATOGRAPHY
PEETERS, A
BUYDENS, L
MASSART, DL
SCHOENMAKERS, PJ
[J]. CHROMATOGRAPHIA, 1988, 26 : 101 - 109
[10] AN EXPERT SYSTEM FOR THE OPTIMIZATION OF COLUMNS, OPERATING-CONDITIONS AND INSTRUMENTATION FOR HIGH-PRESSURE LIQUID-CHROMATOGRAPHY
SCHOENMAKERS, PJ
DUNAND, N
CLELAND, A
MUSCH, G
BLAFFERT, T
[J]. CHROMATOGRAPHIA, 1988, 26 : 37 - 44

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