1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE, DECREASING IN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED MOUSE, PREVENTS PARKINSONISM-LIKE BEHAVIOR ABNORMALITIES

被引：109

作者：

TASAKI, Y ^{[1
]}

MAKINO, Y ^{[1
]}

OHTA, S ^{[1
]}

HIROBE, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 57卷 / 06期

关键词：

1,2,3,4-TETRAHYDROISOQUINOLINE; 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; PARKINSONISM; ANTIPARKINSONISM AGENTS; BEHAVIOR ABNORMALITIES;

D O I：

10.1111/j.1471-4159.1991.tb06407.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tetrahydroisoquinoline (TIQ), which is well noted for inducting parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), was markedly reduced. This result agrees with the finding in human idiopathic parkinsonianism, confirmed by our previous research. In addition, pretreatment with 1-MeTIQ completely prevented MPTP- or TIQ-inducing bradykinesia, a symptom of parkinsonism. This study confirmed that 1-MeTIQ plays an important role in preventing the pathogenesis of parkinsonism and is a possible leading compound of anti-parkinsonism agents.

引用

页码：1940 / 1943

页数：4

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