THE PROPORTION OF GALANIN-IMMUNOREACTIVE NEURONS IN MOUSE TRIGEMINAL GANGLIA IS TRANSIENTLY INCREASED FOLLOWING CORNEAL INOCULATION OF HERPES-SIMPLEX VIRUS TYPE-1

被引：35

作者：

HENKEN, DB

MARTIN, JR

机构：

[1] Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 02期

关键词：

GALANIN; HERPES SIMPLEX VIRUS TYPE-1; CORNEA; TRIGEMINAL GANGLION; IMMUNOCYTOCHEMISTRY;

D O I：

10.1016/0304-3940(92)90096-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate whether neurobiological functions are modified by viral infection, we inoculated mouse corneas with herpes simplex virus type 1 (HSV-1) and examined neuronal galanin content in trigeminal ganglia at selected survival times. HSV-1 antigen appeared in neurons at day 3, peaked at day 6 and disappeared by day 11. Increased galanin positivity was first seen at day 6, peaked at day 10 and approached control values by day 21. This result provides further evidence that the biological program of peripheral sensory neurons is modified by herpes-virus infection.

引用

页码：177 / 180

页数：4

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