共 1 条
- [1] CLARKE EGC, 1974, ISOLATION IDENTIFICA, V1
THE DETERMINATION OF THE PRESERVATIVE, CHLOROCRESOL, IN A PHARMACEUTICAL FORMULATION BY FLOW-INJECTION ANALYSIS
被引：10
作者：
BLOOMFIELD, MS
PREBBLE, KA
机构：
[1] Analytical Development Laboratories, The Wellcome Foundation Limited, Temple Hill, Dartford
关键词：
FLOW INJECTION ANALYSIS;
CHLOROCRESOL;
LIEBERMANN REACTION;
NITROUS ACID REAGENT;
PHENOL;
PENTOSTAM INJECTION;
D O I：
10.1016/0731-7085(91)80079-O
中图分类号：
O65 [分析化学];
学科分类号：
070302 ;
081704 ;
摘要：
A flow injection analysis (FIA) procedure is described for the determination of chlorocresol in a parenteral pharmaceutical formulation. The product is directly injected into a carrier stream of water and subsequently reacted with a reagent stream of nitrous acid. The resulting brown nitro-derivative is detrmined spectrophotometrically at 400 nm. The method has been validated and should be spplicable to chlorocresol in other pharmaceutical products and to compounds containg a phenolic ring, assuming abscence of matrix interference.
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页码：775 / 778
页数：4
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