GENETIC-MAPPING AND EXPRESSION ANALYSIS OF THE MURINE DNA-LIGASE-I GENE

被引：10

作者：

GARIBOLDI, M

MONTECUCCO, A

COLUMBANO, A

LEDDACOLUMBANO, GM

SAVINI, E

MANENTI, G

PIEROTTI, MA

DRAGANI, TA

机构：

[1] IST NAZL TUMORI,DIV EXPTL ONCOL A,I-20133 MILAN,ITALY

[2] IST GENET BIOCHIM & EVOLUZIONIST,PAVIA,ITALY

[3] UNIV CAGLIARI,IST PATOL SPERIMENTALE,CAGLIARI,ITALY

来源：

MOLECULAR CARCINOGENESIS | 1995年 / 14卷 / 02期

关键词：

CHROMOSOME MAPPING; DNA REPAIR; LIVER REGENERATION; INBRED C3H MICE; MITOGENS;

D O I：

10.1002/mc.2940140202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation. (C) 1995 Wiley-Liss, Inc.

引用

页码：71 / 74

页数：4

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