CLONING AND CHARACTERIZATION OF MURINE CD6

被引：17

作者：

WHITNEY, G

BOWEN, M

NEUBAUER, M

ARUFFO, A

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Seattle, WA 98121

来源：

MOLECULAR IMMUNOLOGY | 1995年 / 32卷 / 01期

关键词：

D O I：

10.1016/0161-5890(94)00166-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lymphocyte antigen CD6 has been extensively studied in humans, but has not been reported in mouse. Here we describe the isolation and characterization of a cDNA clone encoding the murine homologue of the human lymphocyte antigen CD6. Comparison of the predicted amino acid sequence of human and murine CD6 shows that the cytoplasmic domain of murine CD6 is 160 residues longer than that of the human protein. Inspection of the 3' untranslated sequence of the human CD6 clone and the genomic organization of the murine CD6 gene suggests the expression of differentially spliced CD6 polypeptides in both species.

引用

收藏

页码：89 / 92

页数：4

相关论文

共 21 条

[1] THE LYMPHOCYTE GLYCOPROTEIN-CD6 CONTAINS A REPEATED DOMAIN-STRUCTURE CHARACTERISTIC OF A NEW FAMILY OF CELL-SURFACE AND SECRETED PROTEINS [J].

ARUFFO, A ;

MELNICK, MB ;

LINSLEY, PS ;

SEED, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (04) :949-952

[2] MOLECULAR-CLONING OF A CD28 CDNA BY A HIGH-EFFICIENCY COS CELL EXPRESSION SYSTEM [J].

ARUFFO, A ;

SEED, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8573-8577

[3]

BARCLAY AN, 1993, LEUKOCYTE ANTIGEN FA

[4]

BOTT CM, 1994, J IMMUNOL, V153, P1

[5]

CARDENAS L, 1990, J IMMUNOL, V145, P1450

[6] CD5 IS PHOSPHORYLATED ON TYROSINE AFTER STIMULATION OF THE T-CELL ANTIGEN RECEPTOR COMPLEX [J].

DAVIES, AA ;

LEY, SC ;

CRUMPTON, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6368-6372

[7] AN ANCIENT, HIGHLY CONSERVED FAMILY OF CYSTEINE-RICH PROTEIN DOMAINS REVEALED BY CLONING TYPE-I AND TYPE-II MURINE MACROPHAGE SCAVENGER RECEPTORS [J].

FREEMAN, M ;

ASHKENAS, J ;

REES, DJG ;

KINGSLEY, DM ;

COPELAND, NG ;

JENKINS, NA ;

KRIEGER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8810-8814

[8]

GANGEMI RMR, 1989, J IMMUNOL, V143, P2439

[9] MOLECULAR-CLONING OF LY-1, A MEMBRANE GLYCOPROTEIN OF MOUSE LYMPHOCYTES-T AND A SUBSET OF B-CELLS - MOLECULAR HOMOLOGY TO ITS HUMAN COUNTERPART LEU-1/T1 (CD5) [J].

HUANG, HJS ;

JONES, NH ;

STROMINGER, JL ;

HERZENBERG, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (01) :204-208

[10] ISOLATION OF COMPLEMENTARY-DNA CLONES ENCODING THE HUMAN-LYMPHOCYTE GLYCOPROTEIN-T1 LEU-1 [J].

JONES, NH ;

CLABBY, ML ;

DIALYNAS, DP ;

HUANG, HJS ;

HERZENBERG, LA ;

STROMINGER, JL .

NATURE, 1986, 323 (6086) :346-349