ANTIOXIDANT PROPERTIES OF DEHYDROZINGERONE AND CURCUMIN IN RAT-BRAIN HOMOGENATES

被引:64
作者
RAJAKUMAR, DV [1 ]
RAO, MNA [1 ]
机构
[1] COLL PHARMACEUT SCI, DEPT PHARMACEUT CHEM, MANIPAL 576119, INDIA
关键词
CURCUMIN; DEHYDROZINGERONE; LIPID PEROXIDATION; CONJUGATED DIENES; ANTIOXIDANTS;
D O I
10.1007/BF00928368
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascorbate and ferric-ADP-ascorbate. In all these cases, curcumin was more active than dehydrozingerone and dl-alpha-tocopherol.
引用
收藏
页码:73 / 79
页数:7
相关论文
共 40 条
  • [1] ENDOGENOUS OXIDATIVE DNA DAMAGE, AGING, AND CANCER
    AMES, BN
    [J]. FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 7 (3-6): : 121 - 128
  • [2] PHARMACOLOGY OF CURCUMA-LONGA
    AMMON, HPT
    WAHL, MA
    [J]. PLANTA MEDICA, 1991, 57 (01) : 1 - 7
  • [3] OXIDATIVE STRESS IN MOUSE HEART BY ANTITUMORAL DRUGS - A COMPARATIVE-STUDY OF DOXORUBICIN AND MITOXANTRONE
    ARNAIZ, SL
    LLESUY, S
    [J]. TOXICOLOGY, 1993, 77 (1-2) : 31 - 38
  • [4] BONDY SC, 1992, NEUROTOXICOLOGY, V13, P87
  • [5] OXIDATION OF FERROUS IRON DURING PEROXIDATION OF LIPID SUBSTRATES
    BRAUGHLER, JM
    CHASE, RL
    PREGENZER, JF
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 921 (03) : 457 - 464
  • [6] BRAUGHLER JM, 1986, J BIOL CHEM, V261, P282
  • [7] Buege J A, 1978, Methods Enzymol, V52, P302
  • [8] AUTOXIDATION OF BIOLOGICAL MOLECULES .4. MAXIMIZING THE ANTIOXIDANT ACTIVITY OF PHENOLS
    BURTON, GW
    DOBA, T
    GABE, EJ
    HUGHES, L
    LEE, FL
    PRASAD, L
    INGOLD, KU
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (24) : 7053 - 7065
  • [9] CLUFFI M, 1991, NEUROCHEM RES, V16, P43
  • [10] INHIBITORY EFFECT OF CURCUMIN AND SOME RELATED DIETARY COMPOUNDS ON TUMOR PROMOTION AND ARACHIDONIC-ACID METABOLISM IN MOUSE SKIN
    CONNEY, AH
    LYSZ, T
    FERRARO, T
    ABIDI, TF
    MANCHAND, PS
    LASKIN, JD
    HUANG, MT
    [J]. ADVANCES IN ENZYME REGULATION, 1991, 31 : 385 - 396