PATTERN OF CONDENSATION OF MOUSE AND CHINESE-HAMSTER CHROMOSOMES IN G2 AND MITOSIS OF 33258-HOECHST-TREATED CELLS

被引：41

作者：

MARCUS, M ^{[1
]}

NIELSEN, K ^{[1
]}

GOITEIN, R ^{[1
]}

GROPP, A ^{[1
]}

机构：

[1] MED HSCH LUBECK,INST PATHOL,D-2400 LUBECK,FED REP GER

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 122卷 / 01期

关键词：

D O I：

10.1016/0014-4827(79)90574-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The fluorochrome 33258-Hoechst which binds to DNA and preferentially to A-T-rich regions, inhibits drastically the condensation of the centromeric heterochromatic regions in mouse cell lines. Condensation of all other regions of the chromosomes is also inhibited to some extent. The kinetics of condensation-inhibition of the C-heterochromatin indicates that these regions are being condensed at specific time intervals in the G2 period with a specific order of condensation. The C-heterochromatic regions of mouse chromosomes nos. 9, 12, 14, 15 and 16 condense late in G2 and complete their condensation about 30 min before metaphase. Condensation in G2 of Chinese hamster chromosomes is also inhibited by 33258-H treatment. © 1979.

引用

页码：191 / 201

页数：11

共 30 条

[1] ROLE OF NONHISTONE PROTEINS IN METAPHASE CHROMOSOME STRUCTURE [J].