ROLE OF PAIN IN PLACEBO ANALGESIA

被引:85
作者
LEVINE, JD
GORDON, NC
BORNSTEIN, JC
FIELDS, HL
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT ORAL MED,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,CTR LIVER,SAN FRANCISCO,CA 94143
关键词
D O I
10.1073/pnas.76.7.3528
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The hypothesis that perceived pain intensity can influence placebo analgesia was tested. One hundred and seven subjects rate their pain from 0 to 10 on a visual analog scale after a standard wisdom tooth extraction. The expected course of such postoperative pain in the absence of therapy or placebo is a steady increase; this was confirmed by blind administration of the placebo. When placebos were given intravenously in view of the patients, some (placebo nonresponders) reported that their pain increased, whereas others (placebo responders) reported that their pain either decreased or remained the same over the next 60 min. A placebo response was more likely to occur if the pain rating min prior to placebo administration (initial pain) was greater than 2.6. Furthermore, placebo responders with initial pain above this 2.6 level reported significantly greater mean analgesia than those with lower initial pain. Indeed, responders with initial pain less than 2.6 reported no change in pain during the 60 min after administration of a placebo. When their initial pain level was greater than 2.6, they reported a steady decline in pain over this period. However, above the 2.6 level there was no obvious relationship between the magnitude of the placebo analgesia and the initial pain.
引用
收藏
页码:3528 / 3531
页数:4
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