REGIONAL DISTRIBUTION OF AMINO-ACIDS IN FRIEDREICHS ATAXIA BRAINS

被引：32

作者：

HUXTABLE, R

AZARI, J

REISINE, T

JOHNSON, P

YAMAMURA, H

BARBEAU, A

机构：

[1] CLIN RES INST MONTREAL, 110 PINE AVE W, MONTREAL H2W 1R7, QUEBEC, CANADA

[2] UNIV ARIZONA, ARIZONA HLTH SCI CTR, DEPT PHARMACOL, TUCSON, AZ 85724 USA

[3] UNIV ARIZONA, ARIZONA HLTH SCI CTR, DEPT PATHOL, TUCSON, AZ 85724 USA

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1979年 / 6卷 / 02期

关键词：

D O I：

10.1017/S0317167100119742

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The distribution of amino acids in two Friedreich's ataxia brains is compared to 4 control brains. Glutamate and G A BA were decreased in the ce r ebe l-lar hemispheres and/or in the vermis. Taurine concentrations were uniformly elevated throughout the areas studied. Taurine /glutamate and taurine/ GABA ratios were consistently elevated in Friedreich's ataxia brains, whereas glutamate/ glutaminę ratios were consistently decreased (with normal glutaminę concentrations). © 1979, Canadian Neurological Sciences Federation. All rights reserved.

引用

页码：255 / 258

页数：4

共 7 条

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[3] LEMIEUX B, 1976, Canadian Journal of Neurological Sciences, V3, P373
[4] GLUTAMINE SYNTHETASE- GLIAL LOCALIZATION IN BRAIN
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BELL, KP
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[J]. SCIENCE, 1977, 195 (4284) : 1356 - 1358
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[6] REISINE TD, 1979, CAN J NEUROL SCI, V6, P259
[7] TAURINE, COMPARTMENTALIZED METABOLISM OF GLUTAMIC-ACID, AND EPILEPSIES
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[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1978, 56 (03) : 362 - 374

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