STRUCTURAL CHARACTERIZATION OF ANTIGENS ENCODED BY RABBIT RLA-11 HISTOCOMPATIBILITY GENES

被引:21
作者
KIMBALL, ES
COLIGAN, JE
KINDT, TJ
机构
[1] Laboratory of Immunogenetics, Building 8, Room 100, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20014, Maryland
关键词
D O I
10.1007/BF01561430
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Products of rabbit RLA-11 histocompatibility genes were isolated from rabbit lymphoid tumor cells (RL-5) and characterized. The tumor cells were grown in culture with radioactive amino acids and were lysed by treatment with the detergent NP-40. Glycoprotein molecules were isolated by affinity chromatography using immobilized lentil lectin. Chromatography on purified sheep anti-rabbit beta-2-microglobulin yielded a 43,000 dalton glycoprotein fraction, designated RLA-11gp, which was noncovalently associated with beta-2-microglobulin. N-terminal amino acid sequence analysis using radiochemical methods allowed assignment of 28 of the N-terminal 35 residues. The data revealed 89% homology of the RLA-11gp N-terminus with that of the human HLA-B7 and 82% with the mouse H-2Kb histocompatibility antigens. Comparison of the RLA-11 gp N-terminal sequence data obtained in this work to sequence data reported for major histocompatibility complex antigens of other species revealed no amino acid substitutions unique to the rabbit antigens. © 1979 Springer-Verlag New York Inc.
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页码:201 / 211
页数:11
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