REMOVAL OF SILYL PROTECTING GROUPS FROM HYDROXYL FUNCTIONS WITH AMMONIUM FLUORIDE IN METHANOL

被引：215

作者：

ZHANG, WJ ^{[1
]}

ROBINS, MJ ^{[1
]}

机构：

[1] BRIGHAM YOUNG UNIV,DEPT CHEM,PROVO,UT 84602

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(00)91889-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of silyl ethers with excess ammonium fluoride in methanol at 60-degrees-C effected cleavage to alcohols within 5 hours. Deprotection at ambient temperature required 1-2 days. NH4F/MeOH is an economical alternative to TBAF/THF.

引用

页码：1177 / 1180

页数：4

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