AGE-RELATED-CHANGES IN TRANSMITTER GLUTAMATE AND NMDA RECEPTOR CHANNELS IN THE BRAIN OF SENESCENCE-ACCELERATED MOUSE

被引:57
作者
KITAMURA, Y [1 ]
ZHAO, XH [1 ]
OHNUKI, T [1 ]
TAKEI, M [1 ]
NOMURA, Y [1 ]
机构
[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,SAPPORO,HOKKAIDO 060,JAPAN
关键词
GLUTAMATERGIC NEURON; NMDA RECEPTOR CHANNEL; LEARNING AND MEMORY; AGING; HIPPOCAMPUS; CEREBRAL CORTEX; SENESCENCE-ACCELERATED MOUSE;
D O I
10.1016/0304-3940(92)90396-O
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The senescence-accelerated mouse (SAM-P/8) is known as a murine model of aging and memory dysfunction. In the hippocampus and cerebral cortex of P/8, the contents of glutamic acid and glutamine were significantly higher than those of normal strain R/1 during 2 and 14 months. High K+-evoked endogenous glutamic acid release from the slices of P/8 was increased in comparison with R/1 at 9 and 11 months. In addition, the B(max) of [H-3]dizocilpine (MK-801, channel blocker for N-methyl-D-aspartic acid receptor/channel) binding in the cerebral cortex was age-dependently decreased in P/8 but not in R/1. These results suggest that synaptic dysfunctions in the glutamatergic system occur in the CNS of SAM-P/8.
引用
收藏
页码:169 / 172
页数:4
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