ACTION OF INTERLEUKIN-2 AND INTERLEUKIN-4 ON CRF MESSENGER-RNA IN THE HYPOTHALAMUS AND POMC MESSENGER-RNA IN THE ANTERIOR-PITUITARY

被引：27

作者：

HARBUZ, MS ^{[1
]}

STEPHANOU, A ^{[1
]}

KNIGHT, RA ^{[1
]}

CHOVERGONZALEZ, AJ ^{[1
]}

LIGHTMAN, SL ^{[1
]}

机构：

[1] NATL HEART & LUNG INST,DEPT CYST FIBROSIS,LONDON SW3 6LR,ENGLAND

来源：

BRAIN BEHAVIOR AND IMMUNITY | 1992年 / 6卷 / 03期

关键词：

D O I：

10.1016/0889-1591(92)90044-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have used the technique of in situ hybridization histochemistry to determine corticotropin-releasing factor (CRF) mRNA in the hypothalamic paraventricular nucleus (PVN) and proopiomelanocortin (POMC) mRNA in the anterior pituitary of rats given a single ip injection of either interleukin (IL)-2 or IL-4. IL-2 increased POMC mRNA in the anterior pituitary in a dose-dependent manner. The effect was apparent both at 4 and 24 h after injection. No effect of IL-2 on CRF mRNA in the PVN was detected in these animals, suggesting that the increase in POMC mRNA was not driven by an increase in CRF. IL-4 was without effect at the hypothalamic level although this cytokine did result in a decrease in POMC mRNA in the anterior pituitary. © 1992.

引用

页码：214 / 222

页数：9

共 42 条

[1] THE IMMUNE-HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
BATEMAN, A
SINGH, A
KRAL, T
SOLOMON, S
[J]. ENDOCRINE REVIEWS, 1989, 10 (01) : 92 - 112
[2] IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES
BESEDOVSKY, H
DELREY, A
SORKIN, E
DINARELLO, CA
[J]. SCIENCE, 1986, 233 (4764) : 652 - 654
[3] CLEARANCE RATES AND SYSTEMIC EFFECTS OF INTRAVENOUSLY ADMINISTERED INTERLEUKIN-2 (IL-2) CONTAINING PREPARATIONS IN HUMAN-SUBJECTS
BINDON, C
CZERNIECKI, M
RUELL, P
EDWARDS, A
MCCARTHY, WH
HARRIS, R
HERSEY, P
[J]. BRITISH JOURNAL OF CANCER, 1983, 47 (01) : 123 - 133
[4] INTERLEUKIN-2 MODIFIES THE BIOELECTRIC ACTIVITY OF SOME NEUROSECRETORY NUCLEI IN THE RAT HYPOTHALAMUS
BINDONI, M
PERCIAVALLE, V
BERRETTA, S
BELLUARDO, N
DIAMANTSTEIN, T
[J]. BRAIN RESEARCH, 1988, 462 (01) : 10 - 14
[5] DEXAMETHASONE INHIBITS HUMAN INTERLEUKIN-2 BUT NOT INTERLEUKIN-2 RECEPTOR GENE-EXPRESSION INVITRO AT THE LEVEL OF NUCLEAR TRANSCRIPTION
BOUMPAS, DT
ANASTASSIOU, ED
OLDER, SA
TSOKOS, GC
NELSON, DL
BALOW, JE
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (05) : 1739 - 1747
[6] BROWN SL, 1987, J IMMUNOL, V139, P3181
[7] BUZZETTI R, 1988, J ENDOCRINOL, V119, P95
[8] DELPRETE G, 1988, J IMMUNOL, V140, P4193
[9] DELREY A, 1987, ANN NY ACAD SCI, V496, P85
[10] THE NEURO-ENDOCRINE EFFECTS OF INTERLEUKIN-2 TREATMENT
DENICOFF, KD
DURKIN, TM
LOTZE, MT
QUINLAN, PE
DAVIS, CL
LISTWAK, SJ
ROSENBERG, SA
RUBINOW, DR
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (02) : 402 - 410

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