INTERACTIONS IN METAL CARCINOGENICITY

被引:51
作者
BEYERSMANN, D
机构
[1] Department of Biology and Chemistry, University of Bremen
关键词
CADMIUM; CHROMIUM; COBALT; NICKEL; METALS; MUTAGENICITY; CARCINOGENICITY; INTERACTION;
D O I
10.1016/0378-4274(94)90045-0
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The carcinogenicity and genotoxicity of cadmium, chromium, cobalt and nickel strongly depend on their chemical ligands (speciation) which modulate their bioavailability and reactivity with biochemical targets. With the exception of hexavalent chromium, carcinogenic metal compounds are only weakly genotoxic. However, the ions of the carcinogenic metals cadmium, cobalt and nickel, and also the noncarcinogenic lead, inhibit the repair of DNA damaged by direct genotoxic agents like UV irradiation and alkylating substances, thereby enhancing the effects of the latter agents. These effects are interpreted by the interference of the toxic metal ions with biochemical functions of magnesium, calcium and zinc ions.
引用
收藏
页码:333 / 338
页数:6
相关论文
共 22 条
[1]  
[Anonymous], METALS THEIR COMPOUN
[2]  
BEYERSMANN D, 1994, HDB METAL LIGAND INT
[3]  
BLOCK C, 1992, J BIOL CHEM, V267, P19824
[4]  
EBINA Y, 1986, J NATL CANCER I, V76, P107
[5]  
FURST A, 1987, GENOTOXIC CARCINOGEN, P279
[6]   CELLULAR-DAMAGE BY FERRIC NITRILOTRIACETATE AND FERRIC CITRATE IN V79-CELLS - INTERRELATIONSHIP BETWEEN LIPID-PEROXIDATION, DNA STRAND BREAKS AND SISTER CHROMATID EXCHANGES [J].
HARTWIG, A ;
KLYSZCZNASKO, H ;
SCHLEPEGRELL, R ;
BEYERSMANN, D .
CARCINOGENESIS, 1993, 14 (01) :107-112
[7]   ENHANCEMENT OF UV-INDUCED MUTAGENESIS AND SISTER-CHROMATID EXCHANGES BY NICKEL IONS IN V79-CELLS - EVIDENCE FOR INHIBITION OF DNA-REPAIR [J].
HARTWIG, A ;
BEYERSMANN, D .
MUTATION RESEARCH, 1989, 217 (01) :65-73
[8]   INHIBITION OF SARCOPLASMIC-RETICULUM CA2+-ATPASE ACTIVITY BY CADMIUM, LEAD AND MERCURY [J].
HECHTENBERG, S ;
BEYERSMANN, D .
ENZYME, 1991, 45 (03) :109-115
[9]  
HEINRICH U, 1989, EXP PATHOL, V37, P1
[10]  
Lauwerys R R, 1989, Arch Toxicol Suppl, V13, P21