A TRIAL OF THE SYNTHETIC MALARIA VACCINE SPF66 IN TANZANIA - RATIONALE AND DESIGN

被引：27

作者：

ALONSO, PL

TANNER, M

SMITH, T

HAYES, RJ

SCHELLENBERG, JA

LOPEZ, MC

DEAZEVEDO, IB

MENENDEZ, C

LYIMO, E

WEISS, N

KILAMA, WL

TEUSCHER, T

机构：

[1] HOSP CLIN BARCELONA,SECC MED TROP,E-08036 BARCELONA,SPAIN

[2] SWISS TROP INST,BASEL,SWITZERLAND

[3] LONDON SCH HYG & TROP MED,LONDON,ENGLAND

[4] NATL INST MED RES,IFAKARA CTR,AMANI CTR & HEADQUARTERS,IFAKARA,TANZANIA

[5] CSIC,INST PARASITOL LOPEZ NEYRA,GRANADA,SPAIN

来源：

VACCINE | 1994年 / 12卷 / 02期

关键词：

MALARIA VACCINE; PHASE III; AFRICA;

D O I：

10.1016/0264-410X(94)90058-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of a safe, affordable and effective malaria vaccine to form part of control schemes in malaria endemic countries is a priority for researchers and public health officials. SPf66 is the first malaria vaccine to have shown partial protection against natural challenge in a phase III trial carried out in a hypoendemic area of Colombia. This paper describes the rationale and design of the first field trial of SPf66 outside South America, and the first to be conducted in an area of high perennial transmission.

引用

页码：181 / 186

页数：6

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