INHALED NITRIC-OXIDE REVERSES PAP-DEPENDENT BRONCHOCONSTRICTION IN THE PIG

被引：5

作者：

ALBERTINI, M

CLEMENT, MG

机构：

[1] Istituto di Fisiologia Veterinaria e Biochimica, Università di Milano, 20133 Milano

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1995年 / 52卷 / 06期

关键词：

D O I：

10.1016/0952-3278(95)90064-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In six anesthetized, paralyzed, mechanically ventilated pigs we evaluated the respiratory effects of inhaled nitric oxide (NO) (80 ppm in O-2) under control conditions and after platelet-activating factor (PAF) administration (50ng/kg, i.v.). PAF was also administered to the same pigs after pretreatment with indomethacin (3 mg/kg, i.v.). The mechanical properties of the respiratory system were evaluated by the rapid airway occlusion technique. With this technique the overall respiratory resistances, the airway resistances, and the additional resistances of respiratory system and lung can be evaluated. The results show that NO inhaled by the pig at 80 ppm far 6 min under control conditions reduced static and dynamic elastances of the respiratory system and lung and pulmonary arterial pressure, without modifying bronchomotor tone. Therefore, NO reduced the PAF-dependent changes in resistances and in static and dynamic elastances of the respiratory system and lung. The modest change in elastances caused by PAF in pigs pretreated with indomethacin was reduced by NO inhalation, which also has a mild bronchodilatory effect. The changes in elastances appear to be correlated with the pulmonary vasodilator activity of inhaled NO.

引用

页码：373 / 380

页数：8

共 33 条

[1]

Ignarro, Buga, Wood, Byrns, Chaudhuri, Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide, Proc Natl Acad Sci USA, 84, pp. 9265-9269, (1987)

[2]

Palmer, Ferrige, Moncada, Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor, Nature, 327, pp. 524-526, (1987)

[3]

Moncada, Palmer, Higgs, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol Rev, 43, pp. 109-142, (1991)

[4]

Frostell, Fratacci, Wain, Jones, Zapol, Inhaled nitric oxide, A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction, 83, pp. 2038-2047, (1991)

[5]

Gillespie, Sheng, Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular and nonvascular smooth muscle, Br J Pharmacol, 95, pp. 1151-1156, (1988)

[6]

Buga, Gold, Wood, Chaudhuri, Ignarro, Endothelium-derived nitric oxide relaxes nonvascular smooth muscle, Eur J Pharmacol, 161, pp. 61-72, (1989)

[7]

Gruetter, Childers, Bosserman, Lemke, Ball, Valentovic, Comparison of relaxation induced by glyceryl trinitrate, isosorbide dinitrate, and sodium nitroprusside in bovine airways, Am Rev Respir Dis, 139, pp. 1192-1197, (1989)

[8]

Gaston, Drazen, Jansen, Sugarbaker, Loscalzo, Stamler, Relaxation of human airways in vitro by S-nitrosothiols, Am Rev Respir Dis, 145, (1992)

[9]

Ignarro, Lipton, Edwards, Et al., Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates, J Pharmacol Exp Ther, 218, pp. 739-749, (1981)

[10]

Katsuki, Murad, Regulation of adenosine cyclic 3′,5′-monophosphate and guanosine cyclic 3′,5′-monophosphate levels and contractility in bovine tracheal smooth muscle, Mol Pharmacol, 13, pp. 330-341, (1977)

← 1 2 3 4 →