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ALPHA-CHAIN DISEASE - A NEW IMMUNOGLOBULIN ABNORMALITY

被引：274
作者：
SELIGMANN, M
DANON, F
HUREZ, D
MIHAESCO, E
PREUDHOM.JL
机构：
[1] Research Institute on Blood Diseases, Hôpital Saint-Louis
来源：
SCIENCE | 1968年 / 162卷 / 3860期
关键词：
D O I：
10.1126/science.162.3860.1396
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A new type of pathological immunoglobulin was found in the serum, urine, and saliva of a young Arab patient with abdominal lymphoma and diffuse lymphoplasmacytic infiltration of the small intestine. This protein is devoid of light chains and is closely related to the alpha polypeptide chains of the γA1 (Le) subclass of immunoglobulin A. It is characterized by electrophoretic heterogeneity, tendency toward polymerization, and a high carbohydrate content. No intracellular synthesis of light chain was detected.
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页码：1396 / +
页数：1
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