EFFECT OF FR 7534, A NEW CALCIUM ANTAGONIST, ON MYOCARDIAL OXYGEN-DEMAND

被引：19

作者：

JOLLY, SR

GROSS, GJ

机构：

[1] Department of Pharmacology, The Medical College of Wisconsin, Milwaukee, WI 53226

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 54卷 / 03期

关键词：

Calcium antagonist; FR; 7534; Myocardial oxygen demand;

D O I：

10.1016/0014-2999(79)90088-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The actions of FR 7534, a new calcium antagonist, nitroglycerin, and dipyridamole on myocardial oxygen demand have been compared. Six anaesthetized dogs received two infusion levels of each drug which produced equivalent arterial hypotension. All three compounds reduced the tension-time index (TTI). FR 7534 and nitroglycerin but not dipyridamole produced significant decreases in myocardial oxygen consumption (MV̇O2). FR 7534 demonstrated oxygen-sparing actions comparable to nitroglycerin. FR 7534 may prove beneficial in alleviating myocardial ischemia. © 1979.

引用

页码：289 / 293

页数：5

共 8 条

[1] NITROGLYCERIN AND PROPRANOLOL ON MYOCARDIAL O2 CONSUMPTION DURING MYOCARDIAL ISCHEMIA [J].