CONVENIENT SYNTHESES OF N-CD3 LABELED NICOTINE AND NICOTINE ANALOGS

被引：9

作者：

SEEMAN, JI

SECOR, HV

FORREST, G

机构：

[1] Philip Morris Research Center, Richmond, Virginia

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 03期

关键词：

Alkaloids; Methyl Anabasine‐N′‐d[!sub]3[!/sub; Nicotine‐N′‐d[!sub]3[!/sub;

D O I：

10.1002/jlcr.2580160304

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two procedures for the preparation of N‐CD3 labelled nicotine and nicotine analogues are reported. These include: (a) the deuteroiodomethylation of the lithium amide of the corresponding secondary amine; and (b) the alkylation of the corresponding cyclic imine followed by sodium cyanoborohydride reduction of the resulting alkyl iminium salt. Products having both high chemical and isotopic purity are formed. Copyright © 1979 John Wiley & Sons, Ltd.

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页码：387 / 395

页数：9

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